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Lymphocyte to Macrophage Transformation in the Peritoneal Cavity preceding the Mobilization of Peritoneal Macrophages to Inflamed Areas

Nature volume 222, pages 12861288 (28 June 1969) | Download Citation

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Abstract

IT has been shown that most of macrophages in inflammatory exudates arise from rapidly proliferating precursors situated in the bone marrow, some of which may, during their circulatory and migratory phases, resemble small lymphocytes rather than monocytes1–3. My findings suggest that the peritoneal cavity may act as an extravascular “culture chamber” where lymphocytes transform to macrophages before their mobilization to distant inflammatory sites.

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Author information

Affiliations

  1. Department of Morbid Anatomy, Institute of Pathology, The London Hospital, London E1.

    • B. VERNON-ROBERTS

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DOI

https://doi.org/10.1038/2221286a0

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