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Inhibition of CO2 Combination and Reduction of the Bohr Effect in Haemoglobin chemically modified at its α-Amino Groups

Nature volume 222, pages 12431246 (28 June 1969) | Download Citation

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Abstract

Blocking of the α-amino groups by cyanate inhibits the uptake of CO2 by haemoglobin. It also inhibits the influence which changes in pCO2 at constant pH normally have on the oxygen affinity and on the Bohr effect. Blocking the α-amino groups of the α chain reduces the alkaline Bohr effect by 25 per cent.

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Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge

    • J. V. KILMARTIN
  2. Istituto di Chimica Organica, University of Milan, Milan

    • L. ROSSI-BERNARDI

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https://doi.org/10.1038/2221243a0

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