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Prostaglandins and Natriuresis: the Effect of Renal Prostaglandins on PAH Uptake by Kidney Cortex


THE plasma of dogs loaded with saline seems to contain a “natriuretic hormone” which inhibits the reabsorption of sodium by the proximal renal tubule in the rat1. It also seems that plasma from dogs infused with saline will inhibit the uptake of para-aminohippurate (PAH) by slices of rabbit kidney cortex2. We have tried to determine the relationship between these two factors. One class of compounds which has properties common to “natriuretic hormone” and the factor inhibiting PAH uptake is the prostaglandins. Both “natriuretic hormone” and prostaglandins are dialysable and produce an increase in sodium excretion1,3ndash;5. In addition, prostaglandins are capable of exhibiting a 280 mmicron chromophore which is the absorption peak at which Bricker et al. observed inhibition of PAH by saline expanded plasma2. In order to relate prostaglandins, “natriuretic hormone” and the PAH inhibiting factor, we have studied the effect of prostaglandins on PAH accumulation by rabbit kidney cortex in vitro.

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LEE, J., FERGUSON, J. Prostaglandins and Natriuresis: the Effect of Renal Prostaglandins on PAH Uptake by Kidney Cortex. Nature 222, 1185–1186 (1969).

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