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Inhibition of Lymphocyte Recirculation by Heparin

Naturevolume 222pages11831184 (1969) | Download Citation



SMALL lymphocytes recirculate from blood through lymphoid tissues and thence back to blood1. The lymphocytes leave the blood in the spleen by passing between endothelial cells in the marginal zone2 and in the lymph nodes by passing through deep endothelial cells in the post-capillary venules3. These processes must involve specific recognition mechanisms between the emigration sites and lymphocytes in the flowing blood. The mechanisms have been investigated in the rat by incubating thoracic duct lymphocytes with various enzymes in vitro before re-injecting the cells into syngeneic recipients. Pretreatment with neuraminidase inhibited migration into both lymph nodes and spleen4; with trypsin, into lymph nodes only5; and with clostridial glycosidases, and also lymph nodes into the spleen6.

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  1. Department of Pharmacology, Royal College of Surgeons of England, Lincoln's Inn Fields, London, WC2

    • J. W. B. BRADFIELD
    •  & G. V. R. BORN


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