Abstract
THE synthetic double-stranded RNA, polyinosinic : polycytidilic acid (poly I : poly C) exerts its antiviral action by stimulating the production in vitro and in vivo of interferon1–6. Sarma et al.7 found recently that poly I : poly C has a similar inhibitory effect on mouse sarcoma virus (MSV) infection in vivo7 and in vitro (personal communication, P. S. Sarma et al.). We have confirmed the inhibitory effect of poly I : poly C on cellular transformation induced by MSV, and studied its optimal conditions. We also describe the inhibitory effect of poly I : poly C on the growth of Friend leukaemia virus in mouse embryo cells.
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RHIM, J., GKEENAWALT, C. & HUEBNER, R. Synthetic Double-stranded RNA: Inhibitory Effect on Murine Leukaemia and Sarcoma Viruses in Cell Cultures. Nature 222, 1166–1168 (1969). https://doi.org/10.1038/2221166a0
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DOI: https://doi.org/10.1038/2221166a0
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