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Chemical Components in the Cell Wall of Salmonella typhimurium affecting its Virulence and Immunogenicity in Mice

Naturevolume 222pages10851086 (1969) | Download Citation



THE cell wall is the first structure of most bacteria to interact with the host, so its chemical constitution may be important in the relationship between parasite and host. Studies of cell wall lipopolysaccharide (LPS) biosynthesis in Salmonella typhimurium have led to the isolation of a number of mutants which are defective in enzymes catalysing different synthetic steps1,2. We have examined the virulence and immunogenicity of such mutants.

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  1. Department of Microbiology, Keio University School of Medicine, Shinano-machi, Tokyo



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