Letter | Published:

Protection by some Carbamates against the Delayed Neurotoxic Effects of Di-isopropyl Phosphorofluoridate

Nature volume 222, pages 10661067 (14 June 1969) | Download Citation



ADMINISTRATION of a single dose of many organophosphorus esters to hens and other species produces a delayed neurotoxic effect characterized by a flaccid paralysis of hind limbs developing after a symptomless period of 8–14 days (for a review see ref. 1). We have studied the effect produced by di-isopropyl phosphorofluoridate (DFP) because it is a potent neurotoxic compound and does not need to be metabolized to produce the active agent.

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  1. 1.

    , and , Proc. Europ. Soc. Study of Drug Toxicity, 8, 162; Excerpta Med. Int. Cong., Series No. 118 (1966).

  2. 2.

    , Abst. First Int. Meet. Int. Soc. Neurochem., Strasbough, 111 (1967).

  3. 3.

    , Biochem. J., 111, 487 (1969).

  4. 4.

    , Biochem. J., 110, 13P (1968).

  5. 5.

    , Biochem. J. (in the press).

  6. 6.

    see, for instance, , and , Biochem. J., 105, 171 (1967).

  7. 7.

    , Toxic Phosphorus Esters, 100 (Academic Press, New York, 1960).

  8. 8.

    , J. Pharmacol. Exp. Therap., 88, 39 (1946).

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    Visiting worker from the University of Louvain, Belgium.


  1. Biochemical Mechanisms Section, MRC Toxicology Research Unit, Woodmansterne Road, Carshalton, Surrey.

    • M. K. JOHNSON
    •  & R. LAUWERYS


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