Abstract
ADMINISTRATION of gastrin or histamine leads to the secretion of hydrochloric acid by the vertebrate stomach. The details of this process are so far largely unknown. The effects of a variety of hormones in other tissues are mediated by the intracellular level of cyclic AMP (adenosine 3′,5′-monophosphate)1. In several such examples the naturally occurring unsaturated fatty acid, prostaglandin E1 (PGE1), blocks hormonal action. Thus inhibition of epinephrine-induced lipolysis2 and vasopressin-induced changes in osmotic permeability3 by PGE1 have been attributed to interference with the accumulation of cyclic AMP induced by the respective hormone in the target organ or tissue.
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WAY, L., DURBIN, R. Inhibition of Gastric Acid Secretion in vitro by Prostaglandin E1. Nature 221, 874–875 (1969). https://doi.org/10.1038/221874a0
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DOI: https://doi.org/10.1038/221874a0
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