Abstract
HAEMOPOIETIC and immunological activity in radiation chimaeras is related to the proliferation of donor-type cells1–3. Primary stimulation with antigen immediately after transplantation of bone marrow into lethally irradiated animals gave negative results4–6. In these conditions antibody synthesis took place only after transplantation of spleen or lymph node cells1,3,4, which seemed to imply that neither donor bone marrow cells nor recipient cells are involved in antibody synthesis in response to primary stimulation with antigen immediately after irradiation and transplantation. The number of antibody-forming cells in the lymphoid tissue of such animals was not studied, however. Our experiments show that accumulation of antibody-forming cells in lethally irradiated mice protected with syngeneic bone marrow requires the interaction of graft and recipient cells.
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ZARETSKAYA, Y., PANTELEEV, E. & PETROV, R. Accumulation of Antibody-forming Cells in Spleens of Pre-immunized Irradiated Mice after Transplantation of Syngeneic Bone Marrow. Nature 221, 567–568 (1969). https://doi.org/10.1038/221567a0
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DOI: https://doi.org/10.1038/221567a0
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