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Effects associated with Permeability Changes caused by Gramicidin A in Electroplax Membrane

Abstract

In the membrane of the electroplax from the electric organ of Electrophorus electricus, gramicidin A causes an increase of permeability to sodium ions. Cooperative effects are associated with the development of this long lasting change in permeability.

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References

  1. Mueller, P., and Rudin, D. O., Nature, 217, 713 (1968).

    Article  ADS  CAS  Google Scholar 

  2. Pressman, B. C., Harris, E. J., Jagger, W. S., and Johnson, J. H., Proc. US Nat. Acad. Sci., 58, 1949 (1967).

    Article  ADS  CAS  Google Scholar 

  3. Schoffeniels, E., and Nachmansohn, D., Biochim. Biophys. Acta, 26, 1 (1975).

    Article  Google Scholar 

  4. Higman, H., Podleski, T. R., and Bartels, E., Biochim. Biophys. Acta, 75, 182 (1964).

    Google Scholar 

  5. Nachmansohn, D., Chemical and Molecular Basis of Nerve Activity (Academic Press, New York, 1959).

    Google Scholar 

  6. Changeux, J. P., Thiéry, J., Tung, Y., and Kittel, C., Proc. US Nat. Acad. Sci., 57, 335 (1967). Changeux, J. P., and Thiéry, J., in Regulatory Function of Biological Membranes, S. Jusélius Symposium, 116 (Elsevier, 1968). Adam, G., Berichte der Bunsengesellschaft, 71, 831 (1967). Changeux, J. P., and Thiéry, J., J. Theoret. Biol., 17, 315 (1967).

    Google Scholar 

  7. Mullins, L. J., in Molecular Structure and Functional Activity of Nerve Cells, 123 (American Institute of Biological Sciences, 1956). Watanabe, A., Tasaki, I., and Lerman, L., Proc. US Nat. Acad. Sci., 58, 2246 (1967). Karlin, A., J. Theoret. Biol., 16, 306 (1967). Jard, S., Bastide, F., and Morel, F., Biochim. Biophys. Acta, 150, 124 (1968). Hill, T. L., Proc. US Nat. Acad. Sci., 58, 111 (1967).

    Google Scholar 

  8. Changeux, J. P., and Podleski, T. R., Proc. US Nat. Acad. Sci., 59, 944 (1968).

    Article  ADS  CAS  Google Scholar 

  9. Nakamura, Y., Nakajima, S., and Grundfest, H., J. Gen. Physiol., 49, 321 (1965).

    Article  CAS  Google Scholar 

  10. Changeux, J. P., Podleski, T. R., and Wofsy, L., Proc. US Nat. Acad. Sci., 58, 2063 (1967).

    Article  ADS  CAS  Google Scholar 

  11. Karlin, A., and Bartels, E., Biochim. Biophys. Acta, 126, 525 (1966).

    Article  CAS  Google Scholar 

  12. Karlin, A., Proc. US Nat. Acad. Sci., 58, 1162 (1967).

    Article  ADS  CAS  Google Scholar 

  13. Hotchkiss, R. D., Adv. Enzymol., 4, 153 (1944). Bernheimer, A. W., Science, 159, 847 (1968).

    CAS  Google Scholar 

  14. Hodgkin, A. L., and Huxley, A. F., J. Physiol., 117, 500 (1952). Tasaki, I., Nerve Excitation: A Macromolecular Approach, 201 (C. Thomas, Springfield, Illinois, 1968).

    Google Scholar 

  15. Kilbourn, B. T., Dunitz, J. D., Pioda, L. A. R., and Simon, W., J. Mol. Biol., 30, 559 (1967). Shemyakin, M., Ovchinnikov, Y. A., Ivanov, V. T., Antonov, V. K., Shkrob, A. M., Mikhaleva, I. I., Evstratov, A. V., and Malenkov, G. G., Biochem. Biophys. Res. Commun., 29, 834 (1967).

    Article  CAS  Google Scholar 

  16. Morawetz, H. A., Macromolecules in Solution (Interscience, New York, 1965).

    Google Scholar 

  17. Monod, J., Wyman, J., and Changeux, J. P., J. Mol. Biol., 12, 88 (1965). Kirschner, K., Eigen, M., Bittman, R., and Voigt, B., Proc. US Nat. Acad. Sci., 56, 1661 (1966). Changeux, J. P., and Rubin, M. M., Biochemistry, 7, 553 (1968). Buc, M. H., and Buc, H., in Regulation of Enzyme Activity and Allosteric Interactions, Proc. Fourth Meeting Fed. Europ. Biochem. Soc., 107 (Academic Press, 1968).

    Google Scholar 

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PODLESKI, T., CHANGEUX, JP. Effects associated with Permeability Changes caused by Gramicidin A in Electroplax Membrane. Nature 221, 541–545 (1969). https://doi.org/10.1038/221541a0

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