Abstract
A MAJOR, poorly characterized component of human tears migrates more anodally than serum albumin in electrophoresis1. Erickson termed this protein “tear albumin”. When they carried out immunoelectrophoresis of human tears with rabbit anti-human tear serum, Josephson and Lockwood2,3 obtained a precipitin line in the albumin region. This line did not disappear when the anti-tear serum was absorbed with normal human serum. These results1–3 did not exclude the possibility that the tear albumin was a modified form of the albumin or prealbumin found in serum, as was the case with secretory IgA, which consists of serum IgA attached to a “transport piece”4.
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References
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BONAVIDA, B., SAPSE, A. & SERCARZ, E. Specific Tear Prealbumin: a Unique Lachrymal Protein absent from Serum and other Secretions. Nature 221, 375–376 (1969). https://doi.org/10.1038/221375a0
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DOI: https://doi.org/10.1038/221375a0
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