Abstract
WE have studied the effects on rats of sodium cyclamate in amounts corresponding to those consumed by man. Male rats were chosen because differences in weight, food consumption and food efficiency (growth per kcalorie of food) are usually more distinct in males than in females. 101 weanling albino rats, divided into six groups, were given a human type diet in a dried and ground form, composed according to the data on the food consumption of the Dutch population in 1961 (refs. 1 and 2). This “Ran-1961” diet was varied by substituting different compounds for bread and potato starch in isocalorically proportionate amounts. The protein lost by replacing potato and bread was resupplied with cooked potato protein and wheat gluten. Sodium cyclamate was substituted for two-thirds of the sugar in the original diet so that the sweetening effect was the same; that is, in an amount 1/30 of the weight of the sugar. The sugar content of the Ran-1961 diet is 15 kcalories per cent.
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References
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DALDERUP, L., VISSER, W. Effects of Sodium Cyclamate on the Growth of Rats compared with other Variations in the Diet. Nature 221, 91–92 (1969). https://doi.org/10.1038/221091b0
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DOI: https://doi.org/10.1038/221091b0
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