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Comparative Study of the Rh-D Antibody Titres of Amniotic Fluids and Corresponding Maternal Sera in Rh-D Sensitized Pregnancies

Nature volume 221, pages 82–83 (1969)Cite this article

Abstract

IT has been well documented that the severity of erythroblastosis foetalis resulting from maternal Rh factor sensitization is not always proportional to the titre of the mother's serum Rh isoagglutinins1–12. The titre of Rh antibodies in cord serum from Rh negative infants of Rh negative mothers is usually equal to the titre obtained in the maternal serum except for saline agglutinins13. In cases of erythroblastosis resulting from Rh sensitization, however, it is not possible to ascertain how many Rh antibodies have passed into the foetal circulation, for such antibodies are absorbed by the infant's Rh positive cells. Rh antibodies may not be demonstrable in the infant's serum except where excessive amounts (more than necessary to coat all foetal erythrocytes) have been acquired from the mother.

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References

  1. Queenan, J. T., Modern Management of the Rh Problem, 37 (Harper and Row, New York, 1967).

    Google Scholar 

  2. Crawford, J. W., Cameron, C., and Walker, C. H. M., Lancet, i, 887 (1966).

    Article  Google Scholar 

  3. Goodman, H. S., Masaitis, L., and Mizera, G., J. Immunol., 98, 425 (1967).

    CAS  Google Scholar 

  4. Wiener, A. S., Nappi, R., and Gordon, E. B., Blood, 6, 150 (1951).

    Google Scholar 

  5. Cherry, S. H., NY State J. Med., 65, 1226 (1965).

    CAS  Google Scholar 

  6. Jacobs, W. M., Obstet. Gynec., 19, 806 (1962).

    CAS  PubMed  Google Scholar 

  7. Diamond, L. K., Proc. Roy. Soc. Med., 40, 546 (1947).

    CAS  PubMed  Google Scholar 

  8. Allen, jun., F. H., Diamond, L. K., and Jones, A. R., New Engl. J. Med., 251, 453 (1954).

    Article  Google Scholar 

  9. Allen, jun., F. H., and Diamond, L. K., Erythroblastosis Fetalis, 41 (Little Brown and Co., Boston, 1958).

    Google Scholar 

  10. Novell, H. A., and Taylor, P. W., Amer. J. Obst. Gynec., 82, 1379 (1961).

    Article  Google Scholar 

  11. Freda, V. S., Amer. J. Obstet. Gynec., 93, 321 (1965).

    Article  Google Scholar 

  12. Rigsby, W. C., Vorys, N., Copeland, W. E., and Vilery, J. C., Obstet. Gynec., 18, 579 (1961).

    CAS  PubMed  Google Scholar 

  13. Wiener, A. S., Ann. Allergy, 6, 293 (1948).

    CAS  PubMed  Google Scholar 

  14. Queenan, J. T., Modern Management of the Rh Problem, 39 (Harper and Row, New York, 1967).

    Google Scholar 

  15. Lipton, M. M., and Steigman, A. J., Proc. Soc. Exp. Biol. and Med., 96, 348 (1957).

    Article  CAS  Google Scholar 

  16. Ten Broeck, C., and Bauer, J. H., Proc. Soc. Exp. Biol. and Med., 20, 399 (1923).

    Article  Google Scholar 

  17. Magara, M., Jap. J. Exp. Med., 14, 355 (1936).

    CAS  Google Scholar 

  18. Liebling, J., and Schmitz, H. E., J. Pediat., 23, 430 (1943).

    Article  Google Scholar 

  19. Cohen, P., Schneck, H., and Dubow, E., J. Pediat., 38, 696 (1951).

    Article  CAS  Google Scholar 

  20. Vignes, H., Richou, R., and Ramon, P., Rev. Immunol, 12, 1 (1948).

    Google Scholar 

  21. Barr, M., Glenny, A. T., and Randall, K. J., Lancet, ii, 324 (1949).

    Article  Google Scholar 

  22. Bryce, L. M., and Burnett, F. M., J. Pathol. Bact., 35, 183 (1932).

    Article  CAS  Google Scholar 

  23. Plummer, H., J. Immunol., 35, 235 (1938).

    Google Scholar 

  24. Gordon, J. E., and Janney, J. H., J. Pediat., 18, 587 (1941).

    Article  Google Scholar 

  25. Vahlquist, B., Layercrantz, R., and Norbring, F., Lancet, ii, 351 (1950).

    Google Scholar 

  26. Murray, J., Calman, R. M., and Lepine, A., Lancet, ii, 14 (1950).

    Article  Google Scholar 

  27. Adamson, C. A., Lofgrew, S., and Malmnas, C., Scand. J. Clin. Lab. Invest., 3, 52 (1951).

    Article  CAS  Google Scholar 

  28. Murray, J., and Calman, R. M., Brit. Med. J., 13, 15 (1953).

    Google Scholar 

  29. Stuck, B., Natzschka, J., and Wiesener, H., Klein. Wschr., 35, 924 (1957).

    Article  CAS  Google Scholar 

  30. Cohen, P., and Scadron, S. J., J. Amer. Med. Assoc., 121, 656 (1943).

    Article  Google Scholar 

  31. Kendrick, P., Thompson, M., and Eldering, G., Amer. J. Dis. Children, 70, 25 (1945).

    Google Scholar 

  32. Miller, J. J., Faber, H. K., Ryan, M. L., Silverberg, R. J., and Lew, E., Pediatrics, 4, 468 (1949).

    PubMed  Google Scholar 

  33. Kempe, C. H., and Benenson, A. S., J. Pediat., 42, 525 (1953).

    Article  CAS  Google Scholar 

  34. Zuelzer, W. W., and Kaplan, E., Amer. J. Dis. Children, 88, 179 (1952).

    Google Scholar 

  35. Freda, V. S., in The Placental and Fetal Membranes (edit. by Villee, C. A.), 181 (Williams and Wilkins, Baltimore, 1960).

    Google Scholar 

  36. Franco, G., and Gasparini, V., Attual. Ostet. Ginec., 5, 555 (1959).

    Google Scholar 

  37. Coombs, R. R. A., Mourant, A. E., and Race, R. R., Lancet, ii, 15 (1945).

    Article  Google Scholar 

  38. Queenan, J. T., Modern Management of the Rh Problem, 76 (Harper and Row, New York, 1967).

    Google Scholar 

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Authors and Affiliations

  1. Putnam Memorial Hospital, Institute for Medical Research, Bennington, Vermont

    MAGDALENA USATEGUI-GOMEZ & SUSAN STEARNS

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  1. MAGDALENA USATEGUI-GOMEZ
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USATEGUI-GOMEZ, M., STEARNS, S. Comparative Study of the Rh-D Antibody Titres of Amniotic Fluids and Corresponding Maternal Sera in Rh-D Sensitized Pregnancies. Nature 221, 82–83 (1969). https://doi.org/10.1038/221082a0

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