Abstract
STREPTOZOTOCIN, a broad spectrum antibiotic with a unique structure (glucose-NHCON(NO)CH3), has several interesting properties. It is diabetogenic, carcinogenic, carcinostatic and phage-inducing1–4. It has recently been shown to be mutagenic for Salmonella typhimurium in vitro5.
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References
Evans, J., Gerritsen, G., Mann, K., and Owen, S., Cancer Chemotherapy Rep., 48, 1 (1965).
Sugimura, T., and Fujimura, S., Nature, 216, 943 (1967).
Arison, R., and Feudale, E., Nature, 214, 1254 (1967).
Price, K., Buck, R., and Lein, J., Antimicrobial Agents and Chemotherapy, 505 (1964).
Kolbye, S., and Legator, M. S., Mutation Res. (in the press).
Sokolski, W., Vavra, J., and Hanka, L., Antibiot. Ann., 240 (1959–60).
Herr, R., Jahnke, H., and Argoudelis, A., J. Amer. Chem. Soc., 89, 4808 (1967).
Cerda-Olmeda, E., and Hanawalt, D., Biochim. Biophys. Acta, 142, 450 (1967).
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GABRIDGE, M., DENUNZIO, A. & LEGATOR, M. Microbial Mutagenicity of Streptozotocin in Animal-mediated Assays. Nature 221, 68–70 (1969). https://doi.org/10.1038/221068a0
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DOI: https://doi.org/10.1038/221068a0
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