Abstract
AFTER the discovery of the Vibrio cholerae by Koch in 1883, many investigators attempted to develop animal models in a wide variety of species1. Results were erratic and it was not until 1953 that De and Chatterje2 developed the ileal loop in adult rabbits as a model which gave consistent results. Shortly afterwards, Dutta and Habbu3 developed the “suckling bunny” model which also gave consistent results. Since then, these two models have been widely used to study the effects of vibrios and their products on fluid accumulation into the gut lumen. Recently, Carpenter and his colleagues4 developed an animal model using dogs with chronic Thiry-Vella loops in the jejunum and ileum. We report now that the rat can also be used as a cholera model.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Pollitzer, R., Cholera (WHO, Geneva, 1959).
De, S. N., and Chatterje, D. N., J. Pathol. Bact., 66, 559 (1953).
Dutta, N. K., and Habbu, M. K., Brit. J. Pharmacol. Chemother., 10, 153 (1955).
Carpenter, C. C. J., Sack, R. B., Feeley, J. C., and Steenberg, R. W., J. Clin. Invest., 47, 1210 (1968).
Burrows, W., and Musteikis, G. M., J. Infect. Dis., 116, 183 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
AZIZ, K., MOHSIN, A., HARE, W. et al. Using the Rat as a Cholera “Model”. Nature 220, 814–815 (1968). https://doi.org/10.1038/220814a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/220814a0
This article is cited by
-
Biological activity ofTreponema hyodysenteriae hemolysin
Current Microbiology (1981)
-
Comparative study of the effect of cholera toxin and sodium deoxycholate on the paracellular permeability and on net fluid and electrolyte transfer in the rat colon
Naunyn-Schmiedeberg's Archives of Pharmacology (1980)
-
Antagonism of Cholera Enterotoxin by Anti-inflammatory Agents in the Rat
Nature (1972)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
