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Photometric Demonstration of Aggregation of Slime Mould Cells showing Effects of Temperature and Ionic Strength

Nature volume 220, pages 616–618 (1968)Cite this article

Abstract

FOR several years, a photometric method has been in use for the quantitative investigation of the aggregation of thrombocytes or blood platelets1,2. A suspension of platelets in plasma or in physiological saline solution is stirred at a rapid rate in a tube through which a beam of light is passed and the light transmission is recorded continuously. When the platelets are caused to aggregate the transmission increases and when the aggregates disperse the transmission decreases. The dependence of the optical changes on the numbers, sizes and packing densities of the platelet aggregates has been established3. The method has provided much new information about the mechanism of platelet aggregation in relation to haemostasis and thrombosis4. The aggregation of other cells has been followed in the same way5,6.

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Authors and Affiliations

  1. Department of Pharmacology, Royal College of Surgeons of England, Lincoln's Inn Fields,

    G. V. R. BORN & D. GARROD

  2. Department of Biology as Applied to Medicine, Middlesex Hospital Medical School, London

    G. V. R. BORN & D. GARROD

Authors
  1. G. V. R. BORN
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  2. D. GARROD
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BORN, G., GARROD, D. Photometric Demonstration of Aggregation of Slime Mould Cells showing Effects of Temperature and Ionic Strength. Nature 220, 616–618 (1968). https://doi.org/10.1038/220616a0

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