Abstract
THE suppression of immune reactions has helped to analyse their role in controlling neoplastic growths. The frequency of neoplasms which contain virus-specific transplantation antigens usually is strikingly increased in animals thymectomized during the neonatal period or given antilymphocyte serum (ALS). Experimental animals infected with SV 40 virus, adenovirus type 12, and polyoma virus—oncogenic viruses that do not induce tolerance—or with the murine sarcoma virus (MSV) show more tumours at an earlier age if they are thymectomized or treated with ALS (refs. 1–6). In at least one system using induction by polyoma virus of neoplasms in C57B1 mice, the major determinants of tumour induction and control have been shown to be the virus-specific transplantation antigen and the immune response of the tumour bearing host7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Allison, A. C., and Taylor, R. B., Cancer Res., 27, 703 (1967).
Kirschstein, R. L., Rabson, A. S., and Peters, E. A., Proc. Soc. Exp. Biol. and Med., 117, 198 (1964).
Allison, A. C., Berman, L. D., and Levey, R. H., Nature, 215, 185 (1967).
Law, L. W., and Ting, R. C., Proc. Soc. Exp. Biol. and Med., 119, 823 (1965).
Allison, A. C., and Law, L. W., Proc. Soc. Exp. Biol. and Med., 127, 207 (1968).
Law, L. W., Ting, R. C., and Stanton, M. F., J. Nat. Cancer Inst., 40, 1101 (1968).
Law, L. W., Ting, R. C., and Leckband, E., Proc. US Nat. Acad. Sci., 57, 1068 (1967).
Woodruff, M. F. A., and Anderson, N. F., Ann. NY Acad. Sci., 120, 119 (1964).
Monaco, A. P., Wood, A. P., Gray, J. G., and Russell, P. S., J. Immunol., 96, 229 (1966).
Levey, R. H., and Medawar, D. B., Proc. US Nat. Acad. Sci., 56, 1130 (1966).
James, K., and Anderson, N. F., Nature, 213, 1195 (1967).
Berenbaum, M. C., Nature, 215, 1481 (1967).
Stanton, M. L., Law, L. W. and Ting, R. C., J. Nat. Cancer Inst., 40, 1113 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LAW, L., TING, R. & ALLISON, A. Effects of Antilymphocyte Serum on Induction of Tumours and Leukaemia by Murine Sarcoma Virus. Nature 220, 611–612 (1968). https://doi.org/10.1038/220611b0
Received:
Issue Date:
DOI: https://doi.org/10.1038/220611b0
This article is cited by
-
Delayed tumour appearance and absence of regression in nude mice infected with murine sarcoma virus
Nature (1975)
-
T lymphocyte requirement for MSV tumour prevention or regression
Nature (1974)
-
Immunosuppression and neoplasia
Klinische Wochenschrift (1973)
-
Effect of Antilymphocytic Serum on the Appearance of Reticular Neoplasms in SJL/J Mice
Nature (1970)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
