Abstract
THE concern about the psychological and physiological effects of lysergic acid diethylamide (LSD) has naturally led to the desire for experimental models to study the spectra of effects suspected to be caused by LSD. Among the recent reports of its biological effects when pregnant animal models are used, one involving rats is negative1, another2 is ambiguous because although stunted and stillbirths were reported with LSD at 10 days post partum the offspring were unusually large, weighing 44–46 g. Results with hamsters3 are equivocal because of the small incidence of malformations reported, and those for mice are positive4.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Warkany, J., and Takacs, E., Science, 159, 731 (1968).
Alexander, G. J., Miles, B. E., Gold, G. M., and Alexander, R. B., Science, 157, 459 (1967).
Geber, W. F., Science, 158, 265 (1967).
Auerbach, R., and Rugowski, J. A., Science, 157, 1325 (1967).
Ferm, V. H., Lab. Invest., 14, 1500 (1965).
Elis, J., and DiPaolo, J. A., Arch. Pathol., 83, 53 (1967).
DiPaolo, J. A., and Elis, J., Cancer Res., 27, 1696 (1967).
Trasler, D. G., Teratology, 1, 33 (1968).
Gunberg, F. L., Anat. Rec., 130, 310 (1958).
DiPaolo, J. A., Gatzek, H., and Pickren, J., Anat. Rec., 149, 149 (1964).
Trasler, D. G., and Fraser, F. C., quoted by Fraser, F. C., Second Intern. Conf. Congenital Malformations, 277 (New York City, 1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DIPAOLO, J., GIVELBER, H. & ERWIN, H. Evaluation of Teratogenicity of Lysergic Acid Diethylamide. Nature 220, 490–491 (1968). https://doi.org/10.1038/220490b0
Received:
Issue Date:
DOI: https://doi.org/10.1038/220490b0
This article is cited by
-
The effect of LSD on somite number in explanted chick embryos
Experientia (1975)
-
Testing of LSD-25 and related compounds for possible effects on egg-laying capacity and egg-to-adult viability inDrosophila
Experientia (1971)
-
Effect of LSD-25 on mitotic and meiotic chromosomes of mice and monkeys
Human Genetics (1969)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
