ANIMAL experiments have provided a great deal of information about the interaction of drugs early in pregnancy. Little, however, is known of drug action in the late stages of pregnancy1,2. In our previous studies on the damaging effect of sodium salicylate on the foetus, a tendency to premature birth was observed in the mouse when this substance was given on the seventeenth gestation day3. We have therefore investigated the effect of some other anti-inflammatory drugs on the gestation time.
Karnofsky, D. A., Ann. Rev. Pharmacol., 5, 447 (1965).
Tuchmann-Duplessis, H., in Biological Council Symposium on Embryopathic Activity of Drugs, 56 (J. and A. Churchill Ltd, London, 1965).
Larsson, K. S., and Eriksson, M., Acta Paediat. Scand., 55, 569 (1966).
Swartz, D. P., Napolitani, F. D., and Patchell, R. D., Amer. J. Obstet. Gynec., 94, 506 (1966).
Watson, B. P., Amer. J. Obstet. Gynec., 1, 70 (1920).
Jackson, A. V., J. Pathol. Bact., 60, 587 (1948).
Larsson, K. S., Acta Odont. Scand., 20, suppl. 31 (1962).
Larsson, K. S., and Boström, H., Acta Paediat. Scand., 54, 43 (1965).
About this article
Cite this article
ERIKSSON, M., LARSSON, K. Premature Birth induced in Mice by Salicylate. Nature 220, 385 (1968). https://doi.org/10.1038/220385a0
Interactions Between Salicylic Acid and Pyridy;-3-methanol: Anti-inflammatory and Teratogenic Effects
Acta Pharmacologica et Toxicologica (2009)
Safety Assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12–15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate
International Journal of Toxicology (2003)
Seminars in Arthritis and Rheumatism (1988)
Indomethacin induces rat uterine contractions in vitro and alters reactivity to calcium and acetylcholine
American Journal of Obstetrics and Gynecology (1976)
Teratogenic interaction of two substances: Effect of sodium salicylate and defibrase upon pregnant mice
Thrombosis Research (1972)