Abstract
FOB many years the control of blood concentrations of specific metabolites such as amino-acids and nucleic acid precursors has been of much interest in the specific therapy of metabolic deficiencies, cancer and other diseases1. Efforts to do this by injection of specific enzymes have been fraught with difficulties2,3, among which are enzyme purity, poor activity of some enzymes at low substrate concentrations, inability to control the response and the development of sensitivity to the enzymes on repeated injections. For these reasons we decided to find whether blood concentrations of a specific amino-acid, taken as an example, could be controlled through dialysis of the blood against an appropriate enzyme.
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ROGERS, S. Significance of Dialysis against Enzymes to the Specific Therapy of Cancer and Genetic Deficiency Diseases. Nature 220, 1321–1322 (1968). https://doi.org/10.1038/2201321a0
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DOI: https://doi.org/10.1038/2201321a0
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