Abstract
THE similarities between the dysfunctions of Parkinsonism and chronic manganese poisoning have been noted earlier1,2. Evidence has recently suggested that subjects with either of these diseases could have diminished cerebral concentrations of dopamine: dihydroxyphenylalanine (DOPA) has ameliorated Parkinsonians3 in whom diminution of striatal dopamine is an established fact4. The same amino-acid has lessened the rigidity of individuals with chronic manganism1,3, and so it is thought that in these cases, too, there must be a low concentration of dopamine in the brain: DOPA is an immediate precursor of dopamine.
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References
Mena, I., Marin, O., Fuenzalida, S., and Cotzias, G., Neurology, 17, 128 (1967).
Cotzias, G., Horiuchi, K., Fuenzalida, S., and Mena, I., Neurology, 18, 376 (1968).
Cotzias, G., Papavasiliou, P., Gellene, R., and Aronson, R., Trans. of the Proc. Assoc. Amer. Physicians (in the press).
Hornykiewicz, O., Wien. Klin. Wschr., 75, 309 (1963).
Cotzias, G., and Borg, D., Ultra Structure and Metabolism of the Nervous System, 40, 337 (1962).
Cotzias, G., Papavasiliou, P., Van Woert, M., and Sakamoto, A., Fed. Proc., 23, 713 (1964).
Papavasiliou, P., and Cotzias, G., J. Biol. Chem., 236, 2365 (1961).
Bertinchamps, A., Miller, S., and Cotzias, G., Amer. J. Physiol., 211, 217 (1966).
Sutherland, E., and Robison, G., Pharmacol. Rev., 18, 145 (1966).
Sutherland, E., Robison, G., and Butcher, R., Circulation, 37, 279 (1968).
Hughes, E., Miller, S., and Cotzias, G., Amer. J. Physiol., 211, 207 (1966).
Hoffman, W., J. Biol. Chem., 120, 51 (1937).
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PAPAVASILIOU, P., MILLER, S. & COTZIAS, G. Functional Interactions between Biogenic Amines, 3′,5′-cyclic AMP and Manganese. Nature 220, 74–75 (1968). https://doi.org/10.1038/220074a0
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DOI: https://doi.org/10.1038/220074a0
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