Abstract
THE choice of the imperfect mould Penicillium chrysogenum to produce penicillin on an industrial scale1 restricted a genetical approach to increasing penicillin yield, and only methods involving mutation and selection could be used because of the absence of sexuality. Later, the discovery of parasexuality2 and its demonstration in Penicillium chrysogenum3,4 led to several investigations5–8, but none indicated that this genetical recombination process could readily be exploited to produce strains of use to industry.
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HOLT, G., MACDONALD, K. Isolation of Strains with Increased Penicillin Yield after Hybridization in Aspergillus nidulans. Nature 219, 636–637 (1968). https://doi.org/10.1038/219636a0
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DOI: https://doi.org/10.1038/219636a0
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