Abstract
RADIATION1 and viruses2 are implicated in carcinogenesis in man and animals. Kaplan3 has shown that in radiation induced leukaemia in C57Bl mice a virus present in the animal's tissues is the causative agent. Radiation can increase an animal's susceptibility to tumour production by a virus. The direct effect of radiation on the susceptibility of individual cells to tumour viruses can be tested in tissue culture.
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References
Upton, A. C., Carcinogenesis: A Broad Critique, M. D. Anderson Hospital, 631 (Williams and Wilkins, Baltimore, 1967).
Macpherson, I., Brit. Med. Bull., 23, 144 (1967).
Kaplan, H. S., Cancer Res., 27, 1325 (1967).
Todaro, G. J., and Green, H., Virology, 23, 117 (1964).
Todaro, G. J., Green, H., and Swift, M. R., Science, 153, 1252 (1966).
Takemoto, K. K., Kirschstein, R. L., and Habel, K., J. Bact., 92, 990 (1966).
Nilausen, K., and Green, H., Exp. Cell Res., 40, 166 (1965).
Elkind, M. M., and Sutton, H., Radiat. Res., 13, 556 (1960).
Whitmore, G. F., and Gulyas, S., Nat. Cancer Inst. Monograph, 24, 141 (1967).
Sinclair, W., and Morton, R. A., Radiat. Res., 29, 450 (1966).
Stoker, M., Nature, 200, 756 (1963).
Stoker, M., Virology, 24, 123 (1964).
Little, J. B., New England J. Med., 278, 308 (1968).
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POLLOCK, E., TODARO, G. Radiation Enhancement of SV40 Transformation in 3T3 and Human Cells. Nature 219, 520–521 (1968). https://doi.org/10.1038/219520a0
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DOI: https://doi.org/10.1038/219520a0
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