Abstract
HAEMOGLOBIN Köln (α2β298met) (ref. 1) is characterized by increased heat precipitability and abnormal liability to methaemoglobin and Heinz body formation in vitro2,3, like other unstable haemoglobins associated with hereditary Heinz body anaemias4. Excessive detachment of haem groups takes place5, and may be a source of the “dipyrrolic” urinary pigments found in this syndrome6,7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Carrell, R. W., Lehmann, H., and Hutchison, H. E., Nature, 210, 915 (1966).
Hutchison, H. E., Pinkerton, P. H., Waters, P., Douglas, A. S., and Lehmann, D., Brit. Med. J., ii, 1099 (1964).
Vaughan Jones, R., Grimes, A. J., Carrell, R. W., and Lehmann, H., Brit. J. Haemat., 13, 394 (1967).
Heller, P., Amer. J. Med., 41, 799 (1966).
Jacob, H. S., Brain, M. C., and Dacie, J. V., J. Clin. Invest., 46, 1073 (1967).
Kreimer-Birnbaum, M., Pinkerton, P. H., Bannerman, R. M., and Hutchison, H. E., Brit. Med. J., ii, 396 (1966).
Kreimer-Birnbaum, M., Pinkerton, P. H., Bannerman, R. M., and Hutchison, H. E., Blood, 28, 993 (1966).
Sansone, G., Carrell, R. W., and Lehmann, H., Nature, 214, 877 (1967).
Kreimer-Birnbaum, M., and Bannerman, R. M., Brit. J. Haematol., 15, 7 (1968).
Falk, J. E., Porphyrins and Metalloporphyrins (Elsevier, Amsterdam, 1964).
Fessas, P., Loukopoulos, D., and Kaltsoya, A., Biochim. Biophys. Acta, 124, 430 (1966).
Bargellesi, A., Pontremoli, S., Menini, C., and Conconi, F., Europ. J. Biochem., 3, 364 (1968).
Rieder, R. F., Zinkham, W. H., and Holtzman, N. A., Amer. J. Med., 39, 4 (1965).
Grimes, A. J., Meisler, A., and Dacie, J. V., Brit. J. Haematol., 10, 281 (1964).
Dacie, J. V., Shinton, N. K., Gaffney, P. J., Carrell, R. W., and Lehmann, H., Nature, 210, 663 (1967).
Allen, D. W., and Jandl, J. H., J. Clin. Invest., 40, 454 (1961).
Gabuzda, T. G., Laforet, M. T., and Gardner, F. H., J. Lab. Clin. Med., 70, 581 (1967).
Dimant, E., Landsberg, E., and London, I. M., J. Biol. Chem., 213, 769 (1955).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KREIMER-BIRNBAUM, M., PINKERTON, P., BANNERMAN, R. et al. Metabolism of Haemoglobin Köln, an Unstable Haemoglobin. Nature 219, 494–495 (1968). https://doi.org/10.1038/219494a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/219494a0
This article is cited by
-
Identical Substitution in Hb Ube-1 and Hb Köln
Nature New Biology (1973)
-
Hb Frankfurt: Ein neues instabiles H�moglobin als Ursache einer Heinzk�rperan�mie in einer deutschen Sippe
Klinische Wochenschrift (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.