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Metabolism of Haemoglobin Köln, an Unstable Haemoglobin

Abstract

HAEMOGLOBIN Köln (α2β298met) (ref. 1) is characterized by increased heat precipitability and abnormal liability to methaemoglobin and Heinz body formation in vitro2,3, like other unstable haemoglobins associated with hereditary Heinz body anaemias4. Excessive detachment of haem groups takes place5, and may be a source of the “dipyrrolic” urinary pigments found in this syndrome6,7.

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KREIMER-BIRNBAUM, M., PINKERTON, P., BANNERMAN, R. et al. Metabolism of Haemoglobin Köln, an Unstable Haemoglobin. Nature 219, 494–495 (1968). https://doi.org/10.1038/219494a0

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