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Suppression of Contact Hypersensitivity and Acute Inflammation by Anti-complement Serum

Nature volume 219, pages 192–193 (1968)Cite this article

Abstract

IN an analysis of the effect of anti-lymphocyte serum, it has been found that the intravenous injection of the serum—just before skin testing—inhibits the manifestations of contact hypersensitivity to 2,4-dinitrochlorobenzene (DNCB) and acute inflammation caused by intradermal injection of turpentine1,2. We interpreted this as being an effect on the peripheral manifestations of the reactions, and not related to the central effect found in lymphoid tissue2. It seemed likely that both these effects could have been the result of a depletion in the concentration of circulating complement as a result of the in vivo immune reaction involving membranous antigens3.

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References

  1. Waksman, B. H., and Arbouys, S., in Mechanisms of Antibody Formation, Proceedings of a Symposium held in Prague (1959), 165 (New York and London).

    Google Scholar 

  2. Turk, J. L., and Willoughby, D. A., Lancet, i, 249 (1966).

  3. Turk, J. L., Willoughby, D. A., and Stevens, J. E., Immunology (in the press).

  4. Mardiney, M. R., and Müller-Eberhard, H. J., J. Immunol., 94, 877 (1965).

    CAS  PubMed  Google Scholar 

  5. Willoughby, D. A., Walter, M. N-I., and Spector, W. G., Immunology, 8, 578 (1965).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Neveu, T., and Biozzi, G., Immunology, 9, 303 (1965).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Ratnoff, O. D., and Lepow, I. M., J. Exp. Med., 118, 681 (1963).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, St Bartholomew's Hospital Medical College, London

    D. A. WILLOUGHBY

  2. Institute of Dermatology, St John's Hospital for Diseases of the Skin, London

    L. POLÁK & J. L. TURK

Authors
  1. D. A. WILLOUGHBY
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  2. L. POLÁK
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  3. J. L. TURK
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WILLOUGHBY, D., POLÁK, L. & TURK, J. Suppression of Contact Hypersensitivity and Acute Inflammation by Anti-complement Serum. Nature 219, 192–193 (1968). https://doi.org/10.1038/219192a0

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