Abstract
THE preparation and partial purification, from calf thymic tissue, of a soluble product termed thymosin has been reported1. This factor when administered in vivo to normal CBA mice stimulates lymphocytopoiesis with an increase in the weight of lymphoid tissue, an augmented rate of incorporation of 3H-thymidine into the DNA of lymphoid cells, and a peripheral absolute lymphocytosis. In addition, thymosin administration accelerates lymphoid tissue regeneration in CBA mice exposed to whole body X-irradiation (unpublished results of A. L. Goldstein, S. Banerjee, T. F. Dougherty and A. White). The properties of the purified lymphocytopoietic fraction suggest that activity is associated with a relatively heat stable protein. The product therefore does not seem to be identical with any of the previously described thymic preparations2–8.
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LAW, L., GOLDSTEIN, A. & WHITE, A. Influence of Thymosin on Immunological Competence of Lymphoid Cells from Thymectomized Mice. Nature 219, 1391–1392 (1968). https://doi.org/10.1038/2191391a0
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DOI: https://doi.org/10.1038/2191391a0
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