Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Drugs which affect the Structure and Function of DNA

Abstract

Some antimicrobial drugs seem to function by combining with DNA, distorting its structure and function. This article provides a detailed description of three such modes of action.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Maden, B. E. H., Traut, R. R., and Monro, R. E., J. Mol. Biol., 35, 333 (1968).

    Article  CAS  Google Scholar 

  2. Waring, M. J., J. Mol. Biol., 13, 269 (1965).

    Article  CAS  Google Scholar 

  3. Waring, M. J., Biochim. Biophys. Acta, 114, 234 (1966).

    Article  CAS  Google Scholar 

  4. Lerman, L. S., J. Mol. Biol., 3, 18 (1961).

    Article  CAS  Google Scholar 

  5. Lerman, L. S., J. Cell. Comp. Physiol., 64 (Suppl. 1), 1 (1964).

    Article  CAS  Google Scholar 

  6. Fuller, W., and Waring, M. J., Ber. Bunsenges. Physik. Chem., 68, 805 (1964).

    Article  CAS  Google Scholar 

  7. Cairns, J., Cold Spring Harbor Symp. Quant. Biol., 27, 311 (1962).

    Article  CAS  Google Scholar 

  8. Crawford, L. V., and Waring, M. J., J. Mol. Biol., 25, 23 (1967).

    Article  CAS  Google Scholar 

  9. Crawford, L. V., and Waring, M. J., J. Gen. Virol., 1, 387 (1967); Bujard, H., J. Mol. Biol., 33, 503 (1968); Ruttenberg, G. J. C. M., Smit, E. M., Borst, P., and Van Bruggen, E. F. J., Biochim. Biophys. Acta, 157, 429 (1968).

    Article  CAS  Google Scholar 

  10. Bauer, W., and Vinograd, J., J. Mol. Biol., 33, 141 (1968).

    Article  CAS  Google Scholar 

  11. Hudson, B., and Vinograd, J., Nature, 216, 647 (1967).

    Article  ADS  CAS  Google Scholar 

  12. Crick, F. H. C., Barnett, L., Brenner, S., and Watts-Tobin, R. J., Nature, 192, 1227 (1961); Barnett, L., Brenner, S., Crick, F. H. C., Shulman, R. G., and Watts-Tobin, R. J., Phil. Trans., B, 252, 487 (1967).

    Article  ADS  CAS  Google Scholar 

  13. Berger, H., Brammar, W. J., and Yanofsky, C., J. Mol. Biol., 34, 219 (1968).

    Article  CAS  Google Scholar 

  14. Brenner, S., Barnett, L., Crick, F. H. C., and Orgel, A., J. Mol. Biol., 3, 121 (1961); Streisinger, G., Okada, Y., Emrich, J., Newton, J., Tsugita, A., Terzaghi, E., and Inouye, M., Cold Spring Harbor Symp. Quant. Biol., 31, 77 (1966).

    Article  CAS  Google Scholar 

  15. Lerman, L. S., Proc. US Nat. Acad. Sci., 49, 94 (1963).

    Article  ADS  CAS  Google Scholar 

  16. Drake, J. W., J. Cell. Comp. Physiol., 64 (Suppl. 1), 19 (1964).

    Article  CAS  Google Scholar 

  17. Reich, E., Shatkin, A. J., and Tatum, E. L., Biochim. Biophys. Acta, 53, 132 (1961).

    Article  CAS  Google Scholar 

  18. Iyer, V. N., and Szybalski, W., Proc. US Nat. Acad. Sci., 50, 355 (1963).

    Article  ADS  CAS  Google Scholar 

  19. Szybalski, W., and Iyer, V. N., Fed. Proc., 23, 946 (1964).

    CAS  PubMed  Google Scholar 

  20. Szybalski, W., and Iyer, V. N., Microbial Genetics Bull., No. 21, 16 (1964).

  21. Lipsett, M. N., and Weissbach, A., Biochemistry, 4, 206 (1965).

    Article  CAS  Google Scholar 

  22. Murakami, H., J. Theoret. Biol., 10, 236 (1966).

    Article  CAS  Google Scholar 

  23. Boyce, R. P., and Howard-Flanders, P., Z. Vererbungslehre, 95, 345 (1964).

    CAS  Google Scholar 

  24. Kersten, H., Kersten, W., Leopold, G., and Schneiders, B., Biochim. Biophys. Acta, 80, 521 (1964).

    CAS  PubMed  Google Scholar 

  25. Szybalski, W., and Iyer, V. N., in Antibiotics, 1, Mechanism of Action (edit. by Gottlieb, D., and Shaw, P. D.), 211 (Springer-Verlag, New York, 1967).

    Book  Google Scholar 

  26. Dressler, D. H., and Denhardt, D. T., Nature, 219, 346 (1968).

    Article  ADS  CAS  Google Scholar 

  27. Kirk, J. M., Biochim. Biophys. Acta, 42, 167 (1960).

    Article  CAS  Google Scholar 

  28. Hurwitz, J., Furth, J. J., Malamy, M., and Alexander, M., Proc. US Nat. Acad. Sci., 48, 1222 (1962).

    Article  ADS  CAS  Google Scholar 

  29. Reich, E., and Goldberg, I. H., Prog. Nucleic Acid Res. Mol. Biol., 3, 183 (1964).

    Article  CAS  Google Scholar 

  30. Montagnier, L., Symp. Soc. Gen. Microbiol., 18, 125 (1968).

    CAS  Google Scholar 

  31. News and Views, Nature, 219, 679 (1968).

  32. Reich, E., Symp. Soc. Gen. Microbiol., 16, 266 (1966); Reich, E., Cerami, A., and Ward, D. C., in Antibiotics, 1, Mechanism of Action (edit. by Gottlieb, D., and Shaw, P. D.), 714 (Springer–Verlag, New York, 1967).

    Google Scholar 

  33. Cerami, A., Reich, E., Ward, D. C., and Goldberg, I. H., Proc. US Nat. Acad. Sci., 57, 1036 (1967).

    Article  ADS  CAS  Google Scholar 

  34. Hamilton, L., Fuller, W., and Reich, E., Nature, 198, 538 (1963).

    Article  ADS  CAS  Google Scholar 

  35. Müller, W., and Crothers, D. M., J. Mol. Biol., 35, 251 (1968).

    Article  Google Scholar 

  36. Waring, M. J., Symp. Soc. Gen. Microbiol., 16, 235 (1966).

    CAS  Google Scholar 

  37. Lerman, L. S., Proc. Fifth National Cancer Conference, Philadelphia, 39 (Lippincott, 1964); Lesko, jun., S. A., Smith, A., Ts'o, P. O. P., and Umans, R. S., Biochemistry, 7, 434 (1968); Green, B., and McCarter, J. A., J. Mol. Biol., 29, 447 (1967).

    Google Scholar 

  38. Kodama, M., J. Biochem. (Japan), 61, 162 (1967).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

WARING, M. Drugs which affect the Structure and Function of DNA. Nature 219, 1320–1325 (1968). https://doi.org/10.1038/2191320a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/2191320a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing