Abstract
IN his review of the recently published book Tobacco and Tobacco Smoke by Wynder and Hoffmann, Professor Passey1 draws attention to the discrepancy between results of painting cigarette smoke condensate on the skin of mice in the United States and Great Britain. Results of Wynder et al.2, who obtained in America 44.4 per cent of skin carcinomata from a group of eighty-one mice, are compared with 3–5 per cent obtained by workers in Great Britain. Day's work is quoted in support of these low percentages3, and a figure of 3 per cent of 7,875 mice seems to confirm the apparent very low Carcinogenicity. This total, however, includes 1,320 untreated controls and 660 mice treated with the solvent control.
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References
Passey, R. D., Nature, 218, 5149 (1968).
Wynder, E. L., Graham, E. A., and Croninger, Adele B., Cancer Res., 13, 855 (1953).
Day, T. D., Brit. J. Cancer, 21, 56 (1967).
Wynder, E. L., and Hoffmann, D., Tobacco and Tobacco Smoke, 142 (Academic Press, New York, 1967).
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DAVIES, R., DAY, T. Carcinogenicity of Tobacco Smoke Condensate to Mouse Skin. Nature 219, 1183 (1968). https://doi.org/10.1038/2191183a0
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DOI: https://doi.org/10.1038/2191183a0
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