Abstract
HOLTEN et al.1 have reported that the induction of tyrosine transaminase (L-tyrosine-2-oxoglutaric acid aminotransferase, E.C. 2.6.1.5) by large doses of pyridoxine, previously described by Greengard and Gordon2, is inhibited by actinomycin. They concluded that in this respect the induction resembles that initiated by hydrocortisone and other hormones1–7, and therefore suggested that the effect of pyridoxine can be mediated by hormonal factors. Glucocorticoid hormones must be excluded as mediators, for two groups have found1,2 that pyridoxine is effective in adrenalectomized rats. Relationships between pyridoxine and thyroid hormones8,9 and pyridoxine and diabetes10–12, however, have also been recognized. With this concept in mind, we have investigated the effect of pyridoxine on tyrosine transaminase when injected into thyrotoxic and thyroidectomized rats on the one hand, and into alloxan diabetic animals on the other hand. We report here the results of these experiments.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Holten, D., Wicks, W. D., and Kenney, F. T., J. Biol. Chem., 242, 1053 (1967).
Greengard, O., and Gordon, M., J. Biol. Chem., 238, 3708 (1963).
Lin, E. C. C., and Knox, W. E., Biochim. Biophys. Acta, 26, 85 (1957).
Greengard, O., and Baker, G. T., Science, 154, 1461 (1966).
Csanyi, V., Greengard, O., and Knox, W. E., J. Biol. Chem., 242, 2688 (1967).
Kenney, F. T., J. Biol. Chem., 242, 4367 (1967).
Holten, D., and Kenney, F. T., J. Biol. Chem., 242, 4372 (1967).
Capretti, G., and Magni, B., Giorn. Clin. Med., Parma, 32, 417 (1957) quoted by Rawson, R. W., Rall, J. E., and Sonenberg, M., The Hormones, 3, 433 (Academic Press, New York, 1955).
Wohl, M. G., Levy, H. A., Szutka, A., and Maldia, G., Proc. Soc. Exp. Biol. and Med., 105, 523 (1960).
Kotake, jun., Y., and Inada, T., J. Biochem., Tokyo, 40, 287, 291 (1953).
Kotake, jun., Y., and Sani, S., J. Biochem., Tokyo, 40, 295 (1953).
Huber, A. H., Gershoff, S. N., and Hegsted, D. M., J. Nutrit., 82, 371 (1964).
Potter, V. R., Gebert, R. A., Pitot, H. C., Peraino, C., Lamar, jun., C., Lesher, S., and Morris, H. P., Cancer Res., 26, 1547 (1966).
Goswami, M. N. D., and Chatagner, F., Experientia, 22, 370 (1966).
Rivlin, R. S., and Levine, R. J., Endocrinology, 73, 103 (1963).
Litwack, G., Al-Nejjar, Z. H., Sears, M. L., and Ostheimer, G. W., Nature, 201, 1028 (1964).
Rivlin, R. S., J. Biol. Chem., 238, 3341 (1963).
Kenney, F. T., Advances in Enzyme Regulation, 1, 137 (1963).
Rosen, F., Harding, H. R., Milholland, R. J., and Nichol, C. A., J. Biol. Chem., 238, 3725 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CHATAGNER, F., HEIJENOORT, Y. & PORTEMER, C. Modification of the Pyridoxine-induction of Tyrosine Transaminase in Rat Liver by Thyroid Hormones and by Alloxan Diabetes. Nature 218, 566–567 (1968). https://doi.org/10.1038/218566a0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1038/218566a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
