Abstract
BECAUSE uncontrolled production of metabolites is rare in nature it has been concluded that the ability to regulate biosynthetic pathways confers an evolutionary advantage on a species. The advantage has been interpreted as arising from a more efficient use of energy which leads to more rapid growth in a competitive environment. The advantage gained by control of a pathway can thus be estimated by comparing the relative growth rates of two strains which are isogenic, except that one lacks control of the pathway.
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References
Baich, A., and Pierson, D. J., Biochem. Biophys. Acta, 104, 397 (1965).
Tristram, H., and Thurston, C. F., Nature, 212, 74 (1966).
Zamenhof, S., and Eichhorn, H. H., Nature, 216. 456 (1967).
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BAICH, A., JOHNSON, M. Evolutionary Advantage of Control of a Biosynthetic Pathway. Nature 218, 464–465 (1968). https://doi.org/10.1038/218464a0
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DOI: https://doi.org/10.1038/218464a0
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