Abstract
MITOMYCIN C, an effective anti-cancer agent, is also a potent inducer of λ-phage formation in lysogenic Escherichia coli K12 (λ) (refs. 1 and 2). In this report we show that mitomycin-induced phage formation and cell lysis can be suppressed when E. coli K12 (λ) cells are exposed to light from a projection lamp.
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Change history
01 May 1968
In the communication "Photosuppression of Mitomycin-induced X-Phage Development" by Toshiyo Takeno, Takeshi Nagata and Tamitaro Mizunoya (Nature. 218, 295; 1968) the sentences beginning on the fourteenth line of the second paragraph on page 296 should read: "There is no photosuppression when the pre-irradiated cells are incubated with mitomycin C or the cells are incubated with the pre-irradiated mitomycin C.
References
Otsuji, N., Sekiguchi, M., Iijima, T., and Takagi, Y., Nature, 184, 1079 (1959).
Korn, D., and Weissbach, A., Biochim. Biophys. Acta, 61, 775 (1962).
Kaiser, A. D., Virology, 1, 424 (1955).
Iyer, V. N., and Szybalski, W., Science, 145, 55 (1964).
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TAKENO, T., NAGATA, T. & MIZUNOYA, T. Photosuppression of Mitomycin-induced λ-Phage Development. Nature 218, 295–296 (1968). https://doi.org/10.1038/218295b0
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DOI: https://doi.org/10.1038/218295b0
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