Abstract
THE events taking place in the remaining kidney after unilateral nephrectomy have been investigated several times. RNA synthesis, as measured by the uptake of H3-cytidine, is increased within 1 h (ref. 1); protein synthesis is increased by 3 h (ref. 1); DNA synthesis increases by 24–48 h (refs. 2–5); an increase in mitotic activity has been variously reported to occur first at 24–48 h (refs. 5 and 6); and an increase in kidney weight is detectable 30–36 h after nephrectomy5. It is well established that this compensatory renal enlargement consists of both cellular hypertrophy and cellular hyperplasia1, although the number of nephron units apparently remains constant7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Johnson, H. A., and Vera Roman, J. M., Amer. J. Pathol., 49, 1 (1966).
Benitez, L., and Shaka, J. A., Amer. J. Pathol., 44, 961 (1964).
Ogawa, K., Texas Rep. Biol. Med., 19, 825 (1961).
Threlfall, G., Taylor, D. M., and Buck, A. T., Amer. J. Pathol., 50, 1 (1967).
Phillips, T. L., and Lelong, G. F., Cancer Res., 27, 286 (1967).
Goss, R. J., and Rankin, M., J. Exp. Zool., 145, 209 (1960).
Aratkai, M., Amer. J. Anat., 36, 437 (1926).
Lowenstein, L. M., and Stern, A., Science, 142, 1479 (1963).
Simpson, D. P., Amer. J. Physiol., 201, 517 (1961).
Block, M. A., Wakin, K. G., and Mann, F. C., Amer. J. Physiol., 172, 60 (1953).
Katz, A. I., and Epstein, F. H., Third Intern. Nephrology Cong. Abstracts, 218 (1966).
Chignell, C. F., Roddy, P. M., and Titus, E. O., Life Sci., 4, 559 (1965).
Lowry, O. H., Passonneau, J. V., Hasselberger, F. X., and Schulz, D. W., J. Biol. Chem., 239, 18 (1964).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).
Hinman, F., Trans. Amer. Assoc. Genito-Urin. Surg., 15, 241 (1922).
Saphin, O., Amer. J. Pathol., 3, 329 (1927).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FANESTIL, D. Renal Na-K ATPase Relationship to Total Functional Renal Mass. Nature 218, 176–177 (1968). https://doi.org/10.1038/218176a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/218176a0
This article is cited by
-
Mercuric chloride-induced nephrotoxicity in the rat following unilateral nephrectomy and compensatory renal growth
Virchows Archiv B Cell Pathology Including Molecular Pathology (1987)
-
The biology of renal hypertrophy
Kidney International (1986)
-
Renotrophic factors in urine
Kidney International (1983)
-
Circulatory retention of urinary factors as a stimulus to renal growth
Kidney International (1977)
-
Possible significance of histochemical changes of non-specific esterase during compensatory renal growth in the rat
Research in Experimental Medicine (1974)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
