Abstract
SHEEP injected with heterologous glomerular basement membrane (GBM) and Freund's adjuvant (FA) develop progressive glomerulonephritis which is characterized by a linear, continuous deposit of immunoglobulin G (IgG) and β10-globulin (C′3) along the GBM1–3. We have found that IgG eluted from the GBM of nephritic sheep consists largely, if not entirely, of antibodies against the GBM. When these antibodies are injected intravenously into lambs, they seem to react with lamb GBM, fix complement (C′3) and induce glomerular injury.
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STEBLAY, R., RUDOFSKY, U. In vitro and in vivo Properties of Autoantibodies eluted from Kidneys of Sheep with Autoimmune Glomerulonephritis. Nature 218, 1269–1271 (1968). https://doi.org/10.1038/2181269a0
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DOI: https://doi.org/10.1038/2181269a0
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