Abstract
IT has been known for several years that stimulation in infancy has important effects on a variety of behavioural and physiological processes in adulthood1,2. The most common procedure for stimulating infant animals is a technique called “handling”, although other forms of stimulation including electric shock, heat, cold and shaking have also been used3. When rats are handled in infancy it has been well known that, as adults, they will (a) be less emotionally reactive than non-stimulated controls, and (b) have an adrenocortical response pattern very different from that of controls4–6.
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ZARROW, M., PHILPOTT, J., DENENBERG, V. et al. Localization of 14C-4-Corticosterone in the 2 Day Old Rat and a Consideration of the Mechanism involved in Early Handling. Nature 218, 1264–1265 (1968). https://doi.org/10.1038/2181264a0
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DOI: https://doi.org/10.1038/2181264a0
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