Abstract
THERE is increasing evidence that linkage intensity between genes is under genetic control1–4. Fisher5 indicated that linkage intensity is modifiable by natural selection. Following Fisher's suggestion, Kimura6 developed a model of a genetic system which leads to closer linkage by natural selection in diploid organisms, taking into account a mechanism such as inversion for reducing crossing over.
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NEI, M. Evolutionary Change of Linkage Intensity. Nature 218, 1160–1161 (1968). https://doi.org/10.1038/2181160a0
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DOI: https://doi.org/10.1038/2181160a0
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