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New Theory of Cerebral Amine Function and its Clinical Application

Abstract

A comprehensive theory of cerebral amine function unifies biochemical, physiological, psychological and clinical phenomena into a coherent whole. It also provides explanations and valuable tools for further research into normal and abnormal function.

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References

  1. Brodie, B. B., and Costa, E., Psychopharmacol. Serv. Center Bull., 2, No. 5, 1 (1962); (reprinted from Monoamines et Système Nerveux Central, Georg, Geneva, 1962).

    Google Scholar 

  2. Osmond, H., and Smythies, J., J. Ment. Sci., 98, 309 (1952).

    Article  CAS  Google Scholar 

  3. Woolley, D. W., and Shaw, E., Proc. US Nat. Acad. Sci., 40, 228 (1954).

    Article  ADS  CAS  Google Scholar 

  4. Dewhurst, W. G., in Studies in Psychiatry (edit. by Davies, D. L., and Shepherd, M.), (Oxford University Press, London, 1968).

    Google Scholar 

  5. Dewhurst, W. G., thesis, Univ. London (1961).

  6. Dewhurst, W. G., and Marley, E., J. Physiol., 168, 1P (1963).

    Google Scholar 

  7. Dewhurst, W. G., and Marley, E., Brit. J. Pharmacol., 25, 671 (1965).

    PubMed  CAS  Google Scholar 

  8. Dewhurst, W. G., and Marley, E., Brit. J. Pharmacol., 25, 682 (1965).

    PubMed  CAS  Google Scholar 

  9. Dewhurst, W. G., and Marley, E., Brit. J. Pharmacol., 25, 705 (1965).

    CAS  Google Scholar 

  10. Dewhurst, W. G., and Pare, C. M. B., J. Ment. Sci., 107, 239 and 244 (1961).

    Article  CAS  Google Scholar 

  11. Ahlquist, R. P., Amer. J. Physiol., 153, 586 (1948).

    PubMed  CAS  Google Scholar 

  12. Wurtman, R. J., Frank, M. M., Morse, W. H., and Dews, P. B., J. Pharmacol. Exp. Ther., 127, 281 (1959).

    PubMed  CAS  Google Scholar 

  13. Dews, P. B., in Monoamines et Système Nerveux Central (edit. by Ajuriaquerra, J.), 143 (Georg, Geneva, 1962).

    Google Scholar 

  14. Goldstein, L., and Muñoz, C., J. Pharmacol. Exp. Ther., 132, 345 (1961).

    PubMed  CAS  Google Scholar 

  15. Capon, A., Arch. Intern. Pharmacodyn., 127, 141 (1960).

    CAS  Google Scholar 

  16. Muñoz, C., and Goldstein, L., J. Pharmacol. Exp. Ther., 132, 354 (1961).

    PubMed  Google Scholar 

  17. Vane, J. R., Collier, H. O. J., Corne, S. J., Marley, E., and Bradley, P. B., Nature, 191, 1068 (1961).

    Article  ADS  CAS  Google Scholar 

  18. Gaddum, J. H., Neuropsychopharmacology, 2 (edit. by Rothlin, E.), 19 (Elsevier, Amsterdam, 1961).

    Google Scholar 

  19. Vane, J. R., Brit. J. Pharmacol., 14, 87 (1959).

    CAS  Google Scholar 

  20. Fleckenstein, A., and Burn, J. H., Brit. J. Pharmacol., 8, 69 (1953).

    PubMed  CAS  Google Scholar 

  21. Marley, E., J. Physiol., 162, 193 (1962).

    Article  CAS  Google Scholar 

  22. Dewhurst, W. G., J. Psychosom. Res., 9, 115 (1965).

    Article  CAS  Google Scholar 

  23. Dewhurst, W. G., and Marley, E., in Ciba Foundation Symposium on Drug Action on Animal Behaviour (edit. by Steinberg, H., de Reuck, A. V. S., and Knight, A.), 175 (Churchill, London, 1964).

    Google Scholar 

  24. Schildkraut, J. J., Amer. J. Psychiat., 122, 509 (1965).

    Article  CAS  Google Scholar 

  25. Schildkraut, J. J., and Kety, S., Science, 156, 21 (1967).

    Article  ADS  CAS  Google Scholar 

  26. Krnjevic, K., and Phillis, J. W., J. Physiol., 159, 26P (1961).

    Article  Google Scholar 

Download references

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DEWHURST, W. New Theory of Cerebral Amine Function and its Clinical Application. Nature 218, 1130–1133 (1968). https://doi.org/10.1038/2181130a0

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