Abstract
A decrease in the frequency of chiasmata, a change in their location on the chromosome and an increase in the frequency of univalents have been found in mouse oocytes with increasing maternal age. Many of the univalents displayed a non-chiasmate association, others were not associated. Several of these observations evidently apply to man and are perhaps relevant in the aetiology of Down's syndrome and infertility in older mothers.
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HENDERSON, S., EDWARDS, R. Chiasma Frequency and Maternal Age in Mammals. Nature 218, 22–28 (1968). https://doi.org/10.1038/218022a0
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DOI: https://doi.org/10.1038/218022a0
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