Abstract
THE ability of reserpine to bring about the depletion of biologically active amines in mammalian tissues1 is well known. This alkaloid also has several other biochemical effects which have recently been reviewed2, and we report a new and potentially important action of reserpine on catecholamine metabolism which was revealed during the course of another experiment3.
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References
Shore, P. A., Silver, S. L., and Brodie, B. B., Science, 122, 284 (1955).
Carlsson, A., in Heffter's Handbuch der Experimentellen Pharmakologie (edit. by Erspamer, V.), 529 (Springer, Berlin, 1966).
Sandler, M., and Youdim, M. B. H., Biochim. Appl., Parma (in the press).
Pisano, J. J., Crout, J. R., and Abraham, D., Clin. Chim. Acta, 7, 285 (1962).
Ruthven, C. R. J., and Sandler, M., Clin. Chim. Acta, 12, 318 (1965).
McDonald, R. K., and Weise, V. K., J. Pharmacol. Exp. Ther., 136, 26 (1962).
Anton, A. H., and Greer, M., Clin. Pharmacol. Ther., 7, 727 (1966).
Sandler, M., and Ruthven, C. R. J., in Progress in Medicinal Chemistry (edit. by Ellis, G. P., and West, G. B.), 6 (in the press, Butterworth, London, 1968).
Rutledge, C. O., and Weiner, N., J. Pharmacol. Exp. Ther., 157, 290 (1967).
Smith, A., Gitlow, S., Gall, E., Wortis, S. B., and Mendlowitz, M., Clin. Res., 8, 367 (1960).
Davis, V. E., Brown, H., Huff, J. A., and Cashaw, J. L., J. Lab. Clin. Med., 69, 787 (1967).
Davis, V. E., Brown, H., Huff, J. A., and Cashaw, J. L., J. Lab. Clin. Med., 69, 132 (1967).
Tyce, G. M., Flock, E. V., and Owen, jun., C. A., Fed. Proc., 26, 729 (1967).
Goldstein, M., Friedhoff, A. J., Pomerantz, S., and Contrera, J. F., J. Biol. Chem., 236, 1816 (1961).
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SANDLER, M., YOUDIM, M. Promotion of 4-Hydroxy-3-methoxy-phenylglycol Formation in Man by Reserpine. Nature 217, 771–772 (1968). https://doi.org/10.1038/217771a0
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DOI: https://doi.org/10.1038/217771a0
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