Abstract
OROTIC acid, like vitamin B12, increases the RNA1 and free nucleotides2 in the liver of chicks deficient in vitamin B12 and stimulates the incorporation of phosphate labelled with phosphorus-32 into these structures3. More recently, a significant increase in the incorporation of 3H-formate into RNA of subcellular fractions of liver and into acid-soluble free nucleotides has been found in chicks treated with orotic acid4.
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CALDARERA, C., BARBIROLI, B. & MARCHETTI, M. Effect of Orotic Acid on Activity of Nuclear DNA-dependent RNA Polymerase and Polyribosomal Profiles in Deficient Chick Liver lacking Vitamin B12. Nature 217, 755–756 (1968). https://doi.org/10.1038/217755a0
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DOI: https://doi.org/10.1038/217755a0
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