Abstract
THERE have been several reports that decreased food intake blocks collagen cross-linking in. rats1,2. The resulting collagen network is described as younger tissue. Comparing this observation with the classical experiments of McCay3, who increased the life span of experimental animals by reducing their food intake, it seems that a more detailed study of the cross-linking processes is desirable. As far as we know, no data are available which specify the cross-links that are blocked in animals whose food is restricted. Even the fact of whether this change in collagen structure involves only some of the cross-links between the three polypeptide chains of the tropocollagen molecule, or whether it results in a random decrease in cross-link formation, has not yet been investigated.
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References
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DEYL, Z., EVERITT, A. & ROSMUS, J. Changes in Collagen Cross-linking in Rats with Reduced Food Intake. Nature 217, 670–671 (1968). https://doi.org/10.1038/217670a0
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DOI: https://doi.org/10.1038/217670a0
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