Abstract
IT is well known that if in a homologous series of drugs a special group is changed by heavier ones, they gradually change from agonists through partial agonists into competitive antagonists1. It has been reported that isoamyl acetate, its analogues2 and pilocarpine3, some of which are partial agonists, contract the isolated guinea-pig ileum through the liberation of acetylcholine on the one hand, and antagonize the action of released acetylcholine on the other hand, when they combine with the acetylcholine receptor. The sites of action of partial agonists, however, have never been studied precisely, and so we have investigated the effects of cooling, cocaine, morphine and hexa-methonium on the actions of two series of drugs which are esters of choline and dimethylaminoethanol.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Ariens, E. J., Molecular Pharmacology, 1 (Academic Press, New York, 1964).
Tagaki, K., and Takayanagi, I., J. Pharm. Pharmac., 18, 795 (1966).
Takagi, K., Takayanagi, I., and Shih, C. K., Chem. Pharm. Bull., 15, 1747 (1967).
Kosterlitz, H. W., and Lees, G. M., Pharmac. Rev., 16, 301 (1964).
Takagi, K., and Takayanagi, I., Jap. J. Pharmac., 16, 211 (1966).
van Rossum, J. M., Arch Intern. Pharmacodyn. Thér., 143, 299 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TAKAGI, K., TAKAYANAGI, I., TAGA, F. et al. Sites of Action of some Partial Agonists on the Isolated Guinea-pig Ileum. Nature 217, 573–574 (1968). https://doi.org/10.1038/217573a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/217573a0
This article is cited by
-
A transient state concept of drug receptor interaction
Naunyn-Schmiedeberg's Archives of Pharmacology (1973)
-
Electrophysiological Experiments on the Action of Some Partial Agonists and their Application to Receptor Theory
Nature (1968)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
