Abstract
IN the usual conditions of marrow culture, haemoglobin synthesis is maintained for only short periods. Kraus (ref. 1 and personal communication) reported on a long-term bone marrow culture method maintained at less than 37° C. In experimenting with this technique, we observed increased foetal (α2γ2) haemoglobin synthesis in culturing adult marrows.
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References
Kraus, L. M., Nature, 192, 1055 (1961).
Huehns, E. R., and Shooter, E. M., J. Med. Genet., 2, 48 (1965).
Betke, K., Marti, H. R., and Schlicht, I., Nature, 184, 1877 (1959).
Bray, G. A., Anal. Biochem., 1, 279 (1960).
Goldberg, I. H., and Rabinowitz, M., Science, 136, 315 (1962).
Wilt, F. H., Amer. Zoologist, 6, 67 (1966).
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HALL, J., MOTULSKY, A. Production of Foetal Haemoglobin in Marrow Cultures of Human Adults. Nature 217, 569–571 (1968). https://doi.org/10.1038/217569a0
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DOI: https://doi.org/10.1038/217569a0
Further reading
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Hemoglobin switching in the salamanderPleurodeles waltlii
Wilhelm Roux's Archives of Developmental Biology (1982)
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Recent developments in Foetal Haemoglobin Research
Humangenetik (1975)
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Evidence for Various Types of Synthesis of Human γ Chains of Haemoglobin in Acquired Haematological Disorders
Nature New Biology (1971)
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Synthesis of Haemoglobins specified by Allelic Genes in Human Heterozygotes
Nature New Biology (1971)
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