Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Late DNA Synthesis in Heterochromatin

An Erratum to this article was published on 30 March 1968

Abstract

It seems to be a rule of chromosome replication that heterochromatin synthesizes its DNA at a later stage than the rest of the chromosome.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Schultz, J., Cold Spring Harbor Symp. Quant. Biol., 12, 179 (1947).

    Article  CAS  Google Scholar 

  2. Caspersson, T. O., Cell Growth and Cell Function, 185 (W. W. Norton, New York, 1950).

    Google Scholar 

  3. Lima-de-Faria, A., Hereditas, 42, 85 (1956).

    Article  Google Scholar 

  4. Lima-de-Faria, A., Science, 130, 503 (1959).

    Article  CAS  ADS  PubMed  Google Scholar 

  5. Lima-de-Faria, A., J. Biophys. Biochem. Cytol., 6, 457 (1959).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Lima-de-Faria, A., Chromosoma, 5, 1 (1952).

    Article  CAS  PubMed  Google Scholar 

  7. Heitz, E., Jahrb. Wiss. Bot., 69, 762 (1928).

    Google Scholar 

  8. Heitz, E., Planta, 12, 775 (1931).

    Article  Google Scholar 

  9. Heitz, E., Z. Zellforch., 20, 237 (1933).

    Article  Google Scholar 

  10. Heitz, E., Biol. Zbl., 54, 588 (1934).

    Google Scholar 

  11. Heitz, E., Z. f. ind. Abst. und Vererbgsl., 70, 402 (1935).

    Google Scholar 

  12. Schultz, J., Cold Spring Harbor Symp. Quant. Biol., 12, 179 (1947).

    Article  CAS  Google Scholar 

  13. Brown, S. W., Science, 151, 417 (1966).

    Article  CAS  ADS  PubMed  Google Scholar 

  14. Darlington, C. D., and La Cour, L., J. Genet., 40, 185 (1940).

    Article  Google Scholar 

  15. White, M. J. D., Animal Cytology and Evolution, 375 (London and New York, Cambridge University Press, 1945).

    Google Scholar 

  16. Lima-de-Faria, A., J. Biophys. Biochem. Cytol., 6, 457 (1959).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Woodard, J., and Swift, H., Exp. Cell Res., 34, 131 (1964); Woodard, J., Gorovsky, M., and Swift, H., Science, 151, 215 (1966).

    Article  CAS  PubMed  Google Scholar 

  18. Boothroyd, E. R., and Lima-de-Faria, A., Hereditas, 52, 122 (1964).

    CAS  Google Scholar 

  19. Lima-de-Faria, A., J. Biophys. Biochem. Cytol., 6, 457 (1959).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Darlington, C. D., and Hague, H., in Chromosomes Today, 1 (edit. by Darlington, C. D., and Lewis, K. R.), Suppl. to Heredity, 19, 102 (1966).

    Google Scholar 

  21. Pelc, S. R., and La Cour, L. F., in The Cell Nucleus (edit. by Mitchell, J. S.), 232 (Butterworth and Co., London, 1960).

    Google Scholar 

  22. Evans, H. J., Exp. Cell Res., 35, 381 (1964).

    Article  CAS  PubMed  Google Scholar 

  23. Kusanagi, A., Chromosoma, 20, 125 (1966).

    Article  Google Scholar 

  24. Barigozzi, C., Dolfini, S., Fraccaro, M., Jiepolo, L., and Raimondi, G. R., Exp. Cell Res., 43, 231 (1966).

    Article  CAS  PubMed  Google Scholar 

  25. Hughes-Schrader, S., Advances in Genetics (edit. by Demerec, M.), 2, 127 (1948).

    Google Scholar 

  26. Baer, D., Genetics, 52, 275 (1965).

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Karnkowska-Gorska, Z., Bulletin de l'Academie Polonaise des Sciences, 8, 353 (1960).

    Google Scholar 

  28. Harnden, D. G., Lancet, ii, 488 (1961).

  29. German, J. L., Trans. NY Acad. Sci., 24, 395 (1962).

    Article  CAS  Google Scholar 

  30. Gilbert, C. W., Muldal, S., Lajtha, L. G., and Rowley, J., Nature, 195, 869 (1962).

    Article  CAS  ADS  PubMed  Google Scholar 

  31. Morishima, A., Grumbach, M. M., and Taylor, J. H., Proc. US Nat. Acad. Sci., 48, 756 (1962).

    Article  CAS  ADS  Google Scholar 

  32. Morishima, A., Grumbach, M. M., and Taylor, J. H., Proc. US Nat. Acad. Sci., 48, 756 (1962).

    Article  CAS  ADS  Google Scholar 

  33. Grumbach, M. M., Morishima, A., and Taylor, J. H., Proc. US Nat. Acad. Sci., 49, 581 (1963).

    Article  CAS  ADS  Google Scholar 

  34. Rowley, J., Muldal, S., Gilbert, C. W., Lajtha, L. G., Lindsten, J., Fraccaro, M., and Kaijser, K., Nature, 197, 251 (1963).

    Article  CAS  ADS  PubMed  Google Scholar 

  35. Atkins, L., Böök, J. A., Gustavson, K.-H., Hansson, O., and Hjelm, M., Cytogenetics, 2, 208 (1963).

    Article  CAS  PubMed  Google Scholar 

  36. Giannelli, F., Lancet, i, 863 (1963).

  37. Mukherjee, B. B., Miller, O. J., Breg, W. R., and Bader, S., Exp. Cell Res., 34, 333 (1964).

    Article  CAS  PubMed  Google Scholar 

  38. Hsu, J. C., and Lockhart, L. H., Hereditas, 52, 320 (1964). Atkins, L., and Gustavson, K. H., Hereditas, 51, 135 (1964).

    Article  Google Scholar 

  39. Atkins, L., Böök, J. A., Gustavson, K.-H., Hansson, O., and Hjelm, M., Cytogenetics, 2, 208 (1963).

    Article  CAS  PubMed  Google Scholar 

  40. Bishop, A., and Bishop, O. N., Nature, 199, 930 (1963).

    Article  CAS  ADS  PubMed  Google Scholar 

  41. Comings, D. E., Cytogenetics, 6, 20 (1967).

    Article  CAS  PubMed  Google Scholar 

  42. Lima-de-Faria, A., and Reitalu, J., J. Cell Biol., 16, 315 (1963).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Lima-de-Faria, A., Reitalu, J., and O'Sullivan, A. M., Chromosoma, 16, 152 (1965).

    Article  CAS  PubMed  Google Scholar 

  44. Taylor, J. H., J. Biophys. Biochem. Cytol., 7, 455 (1960).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Hsu, T. C., J. Cell Biol., 23. 53 (1964).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Schmid, W., Arch. Klaus-Stiff. Verer b. Forsch., 42, 1 (1967).

    CAS  Google Scholar 

  47. Wolf, U., Flinspach, G., Böhm, R., and Ohno, S., Chromosoma, 16, 609 (1965).

    Article  CAS  PubMed  Google Scholar 

  48. Galton, M., Benirschke, K., and Ohno, S., Chromosoma, 16, 668 (1965).

    Article  CAS  PubMed  Google Scholar 

  49. Fraccaro, M., Gustavsson, I., Hulten, M., Lindsten, J., Mannini, A., and Tiepolo, L., Hereditas, 52, 265 (1964).

    Article  Google Scholar 

  50. Benirschke, K., Low, R. J., Brownhill, L. E., Caday, L. B., and De Venecia-Fernandez, J., Chromosoma, 15, 1 (1964).

    Article  CAS  PubMed  Google Scholar 

  51. Tiepolo, L., Fraccaro, M., Hulten, M., Lindsten, J., Mannini, A., and Gen-Ming, L., Cytogenetics, 6, 51 (1967).

    Article  CAS  PubMed  Google Scholar 

  52. Lima-de-Faria, A., Hereditas, 47, 674 (1961).

    Article  CAS  Google Scholar 

  53. Nicklas, R. B., and Jaqua, R. A., J. Cell Biol., 23, 67A (1964).

    Google Scholar 

  54. Hsu, T. C., Schmid, W., and Stubblefield, E., in Role of Chromosomes in Development, 83 (Academic Press, New York, 1964).

    Book  Google Scholar 

  55. Ohno, S., Jainchill, J., and Stenius, C., Cytogenetics, 2, 232 (1963).

    Article  CAS  PubMed  Google Scholar 

  56. Ohno, S., Becak, W., and Becak, M. L., Chromosoma, 15, 14 (1964).

    Article  CAS  PubMed  Google Scholar 

  57. Taylor, J. H., Exp. Cell Res., 15, 350 (1958).

    Article  CAS  PubMed  Google Scholar 

  58. Lima-de-Faria, A., Hereditas, 47, 674 (1961).

    Article  CAS  Google Scholar 

  59. Lima-de-Faria, A., Banchi, N. O., and Nowell, P., Hereditas (in the press).

  60. Allfrey, V. G., and Mirsky, A. E., Cold Spring Harbor Symp. Quant. Biol., 28, 247 (1963).

    Article  CAS  Google Scholar 

  61. Bonner, J., The Molecular Biology of Development, 155 (Clarendon Press, Oxford, 1965).

    Google Scholar 

  62. Berlowitz, L., Proc. US Nat. Acad. Sci., 53, 68 (1965).

    Article  CAS  ADS  Google Scholar 

  63. Frenster, J. H., in The Cell Nucleus—Metabolism and Radiosensitivity, 27 (1966).

    Google Scholar 

  64. Lima-de-Faria, A., Proc. Seventh Intern. Bot. Cong., 217 (1950).

  65. Tjio, J. H., and Levan, A., Anales de la Estacion Experimental de Aula Dei, 2, 21 (1950).

    Google Scholar 

  66. McLeish, J., Heredity, Suppl. 6, 125 (1953).

  67. Brown, S. W., and Nur, U., Science, 145, 130 (1964).

    Article  CAS  ADS  PubMed  Google Scholar 

  68. Heitz, E., Z. f. ind. Abst. und Vererbgsl., 70, 402 (1935).

    Google Scholar 

  69. Taylor, J. H., J. Biophys. Biochem. Cytol., 7, 455 (1960).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Barr, M. L., in The Sex Chromatin (edit. by Moore, K. L.), 128 (Saunders Co., 1966).

    Google Scholar 

  71. Klinger, H. P., and Schwarzacher, H. G., J. Biophys. Biochem. Cytol., 8, 345 (1960).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Atkins, L., Böök, J. A., Gustavson, K.-H., Hansson, O., and Hjelm, M., Cytogenetics, 2, 208 (1963).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

LIMA-DE-FARIA, A., JAWORSKA, H. Late DNA Synthesis in Heterochromatin. Nature 217, 138–142 (1968). https://doi.org/10.1038/217138a0

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/217138a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing