Abstract
INSULIN applied in vitro reduces the internal sodium concentration of rat skeletal muscle1–2 and stimulates the active transport of sodium in sodium-loaded frog muscle3 and in toad bladder4. External application of insulin to single crab muscle fibres in vitro can cause a striking rise in the efflux of sodium5. Insulin stimulates protein synthesis in skeletal muscle in the presence of actinomycin D6,7 and, because it has been shown that this inhibitor does not stop the hormone from stimulating the sodium pump5, it is difficult to decide whether the primary action is on the efflux mechanism or induction of de novo protein synthesis. This communication describes the behaviour of another single symmetric cell, the toad oocyte, towards insulin.
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BITTAR, E., DICK, D. & FRY, D. Action of Insulin on Sodium Efflux from the Toad Oocyte. Nature 217, 1280–1281 (1968). https://doi.org/10.1038/2171280a0
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DOI: https://doi.org/10.1038/2171280a0
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