Abstract
The forty-second amino-acid of the β-chain of human haemoglobin and its equivalent in all known globins (CD1) is phenylalanine; it stabilizes the haem by direct contact. In Haemoglobin Hammersmith, replacement by serine causes instability of the molecule and thereby severe haemolytic Heinz body anaemia.
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References
Grimes, A. J., and Meisler, A., Nature, 194, 190 (1962).
Grimes, A. J., Meisler, A., and Dacie, J. V., Brit. J. Haematol., 10, 281 (1964).
Chernoff, A. I., and Pettit, N. M., Blood, 24, 750 (1964).
Sansone, G., Carrell, R. W., and Lehmann, H., Nature, 214, 877 (1967).
Beale, D., Biochem. J., 103, 129 (1967).
Datta, J., Bhattacharya, K. R., Sen, A., and Roy, D. K., Ann. Biochem., 17, 211 (1957).
Goldstein, J., Königsberg, W., and Hill, R. J., J. Biol. Chem., 238, 2016 (1963).
Gray, W. R., and Hartley, B. S., Biochem. J., 89, 379 (1963).
Smellie, L. B., and Hartley, B. S., Biochem. J., 101, 232 (1966).
Carrell, R. W., Lehmann, H., and Hutchison, H. E., Nature, 210, 915 (1966).
Carrell, R. W., Lehmann, H., Raik, E., and Hunter, E., Nature, 215, 626 (1967).
Perutz, M. F., Kendrew, J. C., and Watson, H. C., J. Mol. Biol., 13, 669 (1965).
Jones, R. T., Brimhall, B., Huisman, T. H. J., Kleihauer, E., and Betke, K., Science, 154, 1024 (1966).
Nirenberg, M., Leder, P., Bernfield, M., Brimacombe, R., Trupin, J., Rottman, F., and O'Neal, C., Proc. US Nat. Acad. Sci., 53, 1161 (1965).
Beale, D., and Lehmann, H., Nature, 207, 259 (1965).
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DACIE, J., SHINTON, N., GAFFNEY, P. et al. Haemoglobin Hammersmith (β 42 (CD1) Phe→Ser). Nature 216, 663–665 (1967). https://doi.org/10.1038/216663a0
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DOI: https://doi.org/10.1038/216663a0
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