Abstract
DURING a recent investigation of the viscosity changes which occur when thrombin is added continuously to fibrinogen, the substrate solution suddenly and rapidly climbed the shaft of a motor driven paddle at about the conventional coagulation point. This phenomenon is familiar to investigators of artificial high polymers as the Weissenberg effect1–3, which is usually observed where the macromolecules or other structures form a network of temporary entanglements or permanent cross-linkages. To our knowledge, the effect has not been noted in the case of fibrin. It occurred to us to investigate whether the appearance of the effect might provide a useful end-point in coagulation studies.
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JANES, D., THOMAS, H. Weissenberg Effect as an End-point in Coagulation Studies. Nature 216, 197–198 (1967). https://doi.org/10.1038/216197a0
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DOI: https://doi.org/10.1038/216197a0
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