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Disodium Cromoglycate (FPL 670) (‘Intal’*): a Specific Inhibitor of Reaginic Antibody–Antigen Mechanisms

Abstract

CHROMONE derivatives exhibiting unusual biological activity have been studied in these laboratories for several years. One of these, disodium cromoglycate (FPL 670), has been found to inhibit specifically the liberation of the mediators of anaphylaxis initiated by the interaction of antigen with reagin type antibodies. It is neither a bronchodilator nor an anti-inflammatory agent and its action is distinct from that of corticosteroids.

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COX, J. Disodium Cromoglycate (FPL 670) (‘Intal’*): a Specific Inhibitor of Reaginic Antibody–Antigen Mechanisms. Nature 216, 1328–1329 (1967). https://doi.org/10.1038/2161328a0

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