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Facilitation of Tumour Growth by Bacillus pertussis

Abstract

SEVERAL Gram negative bacteria or their components can exert a slight but significant inhibitory effect on the growth of tumour isografts1–4. Protection is obtained by administering the bacterial product at various times before the inoculation of the tumour cells. It is thought that these agents cause non-specific stimulation of the immune response against tumour-specific antigens.

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References

  1. Old, L. J., Benacerraf, B., Clarke, D. A., Carswell, E. A., and Stockert, E., Cancer Res., 21, 1281 (1961).

    CAS  PubMed  Google Scholar 

  2. Weiss, D. W., Bonhag, R. S., and DeOme, K. B., Nature, 190, 889 (1961).

    Article  ADS  CAS  Google Scholar 

  3. Woodruff, M. F. A., and Boak, J. L., Brit. J. Cancer, 20, 345 (1966).

    Article  CAS  Google Scholar 

  4. Weiss, D. W., Bonhag, R. S., and Leslie, P., J. Exp. Med., 124, 1039 (1966).

    Article  CAS  Google Scholar 

  5. Floersheim, G. L., Intern. Arch. Allergy, 26, 340 (1965).

    Article  CAS  Google Scholar 

  6. Seiler, K., Arch. Intern. Pharmacodyn., 169, 452 (1967).

    CAS  Google Scholar 

  7. Hopff, W. H., Floersheim, G. L., and Bucher, K., Helv. Physiol. Pharmacol. Acta, 25, 1 (1967).

    CAS  PubMed  Google Scholar 

  8. Old, L. J., Boyse, E. A., Clarke, D. A., and Carswell, E. A., Ann. NY Acad. Sci., 101, 80 (1962).

    Article  ADS  CAS  Google Scholar 

  9. Klein, G., Israel J. Med. Sci., 2, 135 (1966).

    CAS  PubMed  Google Scholar 

  10. Klein, G., Klein, E., and Haughton, G., J. Nat. Cancer Inst., 36, 607 (1966).

    Article  CAS  Google Scholar 

  11. Sjögren, H. O., J. Nat. Cancer Inst., 32, 645 (1964).

    Google Scholar 

  12. Biozzi, G., Benacerraf, B., and Halpern, B. N., Brit. J. Exp. Pathol., 36, 226 (1955).

    CAS  Google Scholar 

  13. Dubos, R. J., and Schaedler, R. W., J. Exp. Med., 104, 53 (1956).

    Article  CAS  Google Scholar 

  14. Salaman, M. H., and Wedderburn, N., Immunology, 10, 445 (1966).

    PubMed Central  Google Scholar 

Download references

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FLOERSHEIM, G. Facilitation of Tumour Growth by Bacillus pertussis. Nature 216, 1235–1236 (1967). https://doi.org/10.1038/2161235a0

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