Subcellular Localization of Entamoeba histolytica Antigen


SERA from patients with amoebiasis have been shown, by immunofluorescence, to react with smears of Entamoeba histolytica and the reaction can be prevented by absorbing the sera with centrifuged sediments of E. histolytica cultures1. This investigation was designed to determine the antigenically active part of the amoeba in this connexion and the results suggest that the activity resides in subcellular cytoplasmic particles of microsomal density, which is in accord with the cytoplasmic distribution of the immunofluorescent staining.

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  1. 1

    Boonpucknavig, S., and Nairn, R. C., J. Clin. Path. (in the press).

  2. 2

    Osada, M., Keio J. Med., 8, 99 (1959).

  3. 3

    Magaudda-Borzi, L., and Pennisi, L., Atti Soc. Pelorit. Sci. Fis. Mat. Nat., suppl., 7, 607 (1961).

  4. 4

    Miller, J. H., Swartzwelder, J. C., and Deas, J. E., J. Parasitol., 47, 577 (1961).

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BOONPUCKNAVIG, S., LYNRAVEN, G., NAIRN, R. et al. Subcellular Localization of Entamoeba histolytica Antigen. Nature 216, 1232–1233 (1967).

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