Molecular Structure of p-Bromocarbobenzoxy-Glycyl-l-Prolyl-l-Leucyl-Glycine


WE have studied by X-ray analysis a series of oligopeptides, such as carbobenzoxy-Gly-Pro(OH), carbobenzoxy-Gly-Pro-Leu(OH), carbobenzoxy-Gly-Pro-Leu-Gly(OH) and carbobenzoxy-Gly-Pro-Leu-Gly-Pro(OH), which were prepared in order to examine the relationship between the structure of collagen and the substrate specificity for the enzyme reaction, of collagenase, and have already reported some of the results1–3. Recently, the three-dimensional analysis of the tetrapeptide, p-bromoearbo-benzoxy-Gly-Pro-Leu-Gly(OH), has been almost completed and a unique conformation was found in its structure.

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UEKI, T., ASHIDA, T., KAKUDO, M. et al. Molecular Structure of p-Bromocarbobenzoxy-Glycyl-l-Prolyl-l-Leucyl-Glycine. Nature 216, 1205–1207 (1967).

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